Ontology highlight
ABSTRACT:
SUBMITTER: Ereno-Orbea J
PROVIDER: S-EPMC3944693 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20140219 Pt 3
Cystathionine β-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water. In humans, deficiency in CBS activity is the most common cause of hyperhomocysteinaemia and homocystinuria. More than 160 pathogenic mutations in the human CBS gene have been described to date. Here, the purification and preliminary crystallographic analysis of the catalytic core of CBS from Saccharomyces cerevisiae (ScCBS) is described which, in con ...[more]