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Glomerular diseases: FSGS.


ABSTRACT: FSGS is a lesion, not a disease. The separation into primary FSGS (a result of immunologic-mediated injury) versus secondary FSGS (related to a variety of causes) is often difficult. Even when this particular issue is carefully evaluated, the therapeutic implications are not always apparent. Newer literature on both biomarker discovery and on the genetic basis of FSGS is reviewed in this context. In addition, the thorny implications of obesity as it relates to the FSGS lesion are discussed. An overall practical algorithmic approach to the management and treatment of the FSGS lesion that integrates these controversial overlap areas is suggested.

SUBMITTER: Bose B 

PROVIDER: S-EPMC3944761 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Glomerular diseases: FSGS.

Bose Bhadran B   Cattran Daniel D  

Clinical journal of the American Society of Nephrology : CJASN 20130829 3


FSGS is a lesion, not a disease. The separation into primary FSGS (a result of immunologic-mediated injury) versus secondary FSGS (related to a variety of causes) is often difficult. Even when this particular issue is carefully evaluated, the therapeutic implications are not always apparent. Newer literature on both biomarker discovery and on the genetic basis of FSGS is reviewed in this context. In addition, the thorny implications of obesity as it relates to the FSGS lesion are discussed. An o  ...[more]

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