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Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.

ABSTRACT: Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.

SUBMITTER: Lemon CM

PROVIDER: S-EPMC3944830 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.

Lemon Christopher M CM Curtin Peter N PN Somers Rebecca C RC Greytak Andrew B AB Lanning Ryan M RM Jain Rakesh K RK Bawendi Moungi G MG Nocera Daniel G DG

Inorganic chemistry 20131021 4

Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor ...[more]

PMID: 24143874

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