Ontology highlight
ABSTRACT:
SUBMITTER: Cox JA
PROVIDER: S-EPMC3944931 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cox Jane A JA LaMora Angela A Johnson Stephen L SL Voigt Mark M MM
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20131123
In zebrafish, cranial sensory circuits form by 4 days post-fertilization. We used a forward genetic screen to identify genes involved in the formation of these circuits. In one mutant allele, sl23, axons arising from the epibranchial sensory ganglia do not form their stereotypical terminal fields in the hindbrain. These embryos also had small eyes and deformed jaws, suggesting a pleiotropic effect. Using positional cloning, a 20-nucleotide deletion in the carbamoyl-phosphate-synthetase2-aspartat ...[more]