Alterations in lung gene expression in streptozotocin-induced diabetic rats.

ABSTRACT: BACKGROUND: Diabetes profoundly affects gene expression in organs such as heart, skeletal muscle, kidney and liver, with areas of perturbation including carbohydrate and lipid metabolism, oxidative stress, and protein ubiquitination. Type 1 diabetes impairs lung function, but whether gene expression alterations in the lung parallel those of other tissue types is largely unexplored. METHODS: Lung from a rat model of diabetes mellitus induced by streptozotocin was subjected to gene expression microarray analysis. RESULTS: Glucose levels were 67 and 260 mg/dl (p?

SUBMITTER: van Lunteren E 

PROVIDER: S-EPMC3945062 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature