Ontology highlight
ABSTRACT:
SUBMITTER: Leung JW
PROVIDER: S-EPMC3945288 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Leung Justin W JW Agarwal Poonam P Canny Marella D MD Gong Fade F Robison Aaron D AD Finkelstein Ilya J IJ Durocher Daniel D Miller Kyle M KM
PLoS genetics 20140306 3
Histone ubiquitinations are critical for the activation of the DNA damage response (DDR). In particular, RNF168 and RING1B/BMI1 function in the DDR by ubiquitinating H2A/H2AX on Lys-13/15 and Lys-118/119, respectively. However, it remains to be defined how the ubiquitin pathway engages chromatin to provide regulation of ubiquitin targeting of specific histone residues. Here we identify the nucleosome acid patch as a critical chromatin mediator of H2A/H2AX ubiquitination (ub). The acidic patch is ...[more]