Ontology highlight
ABSTRACT:
SUBMITTER: Shi Z
PROVIDER: S-EPMC3945308 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Shi Zixiao Z Shen Tianjin T Liu Yanli Y Huang Yuanyuan Y Jiao Jianwei J
The Journal of biological chemistry 20140123 10
Somatic cells can be reprogrammed to neurons and various other cell types with retrovirus or lentivirus. The limitation of this technology is that these genome-integration viruses may increase the risk of gene mutation and cause insertional mutagenesis. We recently found that non-integration adenovirus carrying neuronal transcription factors can induce fibroblasts to neurons. However, the conversion efficiency by the adenovirus is lower than that of the retrovirus or lentivirus. Therefore, it is ...[more]