Modification of hyaluronan by heavy chains of inter-?-inhibitor in idiopathic pulmonary arterial hypertension.
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ABSTRACT:
SUBMITTER: Lauer ME
PROVIDER: S-EPMC3945340 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Modification of hyaluronan by heavy chains of inter-α-inhibitor in idiopathic pulmonary arterial hypertension.
Lauer Mark E ME Aytekin Metin M Comhair Suzy A SA Loftis Jacqueline J Tian Liping L Farver Carol F CF Hascall Vincent C VC Dweik Raed A RA
The Journal of biological chemistry 20140108 10
We previously reported an altered hyaluronan (HA) metabolism in idiopathic pulmonary arterial hypertension (IPAH) lung tissue and cultured smooth muscle cells. Hyaluronan was present in the smooth muscle cell layer surrounding the pulmonary vasculature and in plexigenic lesions. Additionally, cultured pulmonary artery smooth muscle cells produced spontaneous HA "cable" structures, without additional stimuli, that were leukocyte-adhesive. We now present evidence that the HA that accumulates in IP ...[more]
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2021-03-24 | GSE169471 | GEO
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