HMGB1 localization during experimental periodontitis.
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ABSTRACT:
SUBMITTER: Nogueira AV
PROVIDER: S-EPMC3945472 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
HMGB1 localization during experimental periodontitis.
Nogueira Andressa Vilas Boas AV de Souza João Antonio Chaves JA de Molon Rafael Scaf RS Pereira Elyne da Silva Mariano Eda S de Aquino Sabrina Garcia SG Giannobile William V WV Cirelli Joni Augusto JA
Mediators of inflammation 20140220
<h4>Aim</h4>This study sought to investigate the in vitro expression profile of high mobility group box 1 (HMGB1) in murine periodontal ligament fibroblasts (mPDL) stimulated with LPS or IL-1β and in vivo during ligature- or LPS-induced periodontitis in rats.<h4>Material and methods</h4>For the in vivo study, 36 rats were divided into experimental and control groups, and biopsies were harvested at 7-30 d following disease induction. Bone loss and inflammation were evaluated. HMGB1 expression was ...[more]
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