Transcriptional and epigenetic regulation in human islets.
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ABSTRACT:
SUBMITTER: Bramswig NC
PROVIDER: S-EPMC3945729 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Transcriptional and epigenetic regulation in human islets.
Bramswig Nuria C NC Kaestner Klaus H KH
Diabetologia 20131221 3
Gene regulation in human pancreatic endocrine cells is a complex process, governed by genetic and environmental factors and crosstalk between the various endocrine cell types, and between endocrine cells and the metabolic state. Recent advances in gene expression profiling, genome-wide analysis of epigenetic marks, and cell fractionation of human islets into their constitutive cell types have greatly increased our understanding of the complex processes that govern endocrine cell function in heal ...[more]
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