Ontology highlight
ABSTRACT:
SUBMITTER: Chai YS
PROVIDER: S-EPMC3946351 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chai Yu-Shuang YS Yuan Zhi-Yi ZY Lei Fan F Wang Yu-Gang YG Hu Jun J Du Feng F Lu Xi X Jiang Jing-Fei JF Xing Dong-Ming DM Du Li-Jun LJ
PloS one 20140306 6
Berberine is one kind of isoquinoline alkaloid with anti-apoptotic effects on the neurons suffering ischemia. To address the explanation for these activities, the berberine-induced cell cycle arrest during neurons suffering ischemia/reperfusion had been studied in the present study. According to the in vitro neurons with oxygen-glucose deprivation and in vivo ICR mice with cerebral ischemia/reperfusion, it was found that berberine could protect the mRNA of retinoblastoma (Rb) from degradation th ...[more]