Ontology highlight
ABSTRACT:
SUBMITTER: Raju RM
PROVIDER: S-EPMC3946367 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Raju Ravikiran M RM Jedrychowski Mark P MP Wei Jun-Rong JR Pinkham Jessica T JT Park Annie S AS O'Brien Kathryn K Rehren German G Schnappinger Dirk D Gygi Steven P SP Rubin Eric J EJ
PLoS pathogens 20140306 3
Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized that Clp is required for the physiologic turnover of mycobacterial proteins whose accumulation is deleterious to bacterial growth and survival. To identify cellular substrates, we employed quantitative proteomics and transcriptomics to identify the set of proteins that accumulated upon the loss of functional Clp protease. Among the set of poten ...[more]