Conformational preferences of zampanolide and dactylolide.
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ABSTRACT:
SUBMITTER: Larsen EM
PROVIDER: S-EPMC3946545 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Conformational preferences of zampanolide and dactylolide.
Larsen Erik M EM Wilson Matthew R MR Zajicek Jaroslav J Taylor Richard E RE
Organic letters 20131008 20
The solution conformation behavior of the macrolide core of microtubule-stabilizing agents (-)-zampanolide and (-)-dactylolide has been determined through a combination of high-field NMR experiments and computational modeling. Taken together, the results demonstrate that in solution both molecules exist as a mixture of three interconverting conformational families, one of which bears strong resemblance to zampanolide's tubulin-bound conformation. ...[more]
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