Ontology highlight
ABSTRACT:
SUBMITTER: Beach SR
PROVIDER: S-EPMC3946695 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Beach Steven R H SR Dogan Meeshanthini V MV Brody Gene H GH Philibert Robert A RA
Biological psychology 20131102
Exposure to cumulative SES risk in childhood may interact with variability at the serotonin transporter linked polymorphic region (5HTTLPR) to alter DNA methylation across interacting sets of proteins. DNA was obtained from 388 African Americans at age 19. Genotype at the 5HTTLPR was determined, and methylation ratios for C-phosphate-G (CpG) residues were assessed. Exposure to cumulative SES risk was determined using repeated parental reports at ages 11-13. At high SES risk, CpG methylation patt ...[more]