Ontology highlight
ABSTRACT:
SUBMITTER: Pineda E
PROVIDER: S-EPMC3946735 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Pineda Eduardo E Jentsch J David JD Shin Don D Griesbach Grace G Sankar Raman R Mazarati Andrey A
Epilepsy & behavior : E&B 20131118
Attention deficit/hyperactivity disorder (ADHD) is encountered among patients with epilepsy at a significantly higher rate than in the general population. Mechanisms of epilepsy-ADHD comorbidity remain largely unknown. We investigated whether a model of chronic epilepsy in rats produces signs of ADHD, and thus, whether it can be used for studying mechanisms of this comorbidity. Epilepsy was induced in male Wistar rats via pilocarpine status epilepticus. Half of the animals exhibited chronic ADHD ...[more]