C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells.
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ABSTRACT:
SUBMITTER: Douradinha B
PROVIDER: S-EPMC3946857 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells.
Douradinha Bruno B McBurney Sean P SP Soares de Melo Klecia M KM Smith Amanda P AP Krishna Neel K NK Barratt-Boyes Simon M SM Evans Jared D JD Nascimento Eduardo J M EJ Marques Ernesto T A ET
Virus research 20131115
Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infect ...[more]
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