Ontology highlight
ABSTRACT:
SUBMITTER: Tan YX
PROVIDER: S-EPMC3946925 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Tan Ying Xim YX Manz Boryana N BN Freedman Tanya S TS Zhang Chao C Shokat Kevan M KM Weiss Arthur A
Nature immunology 20131208 2
Signaling via the T cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs). To understand how the kinase Csk, a negative regulator of SFKs, controls the basal state and the initiation of TCR signaling, we generated mice that express a Csk variant sensitive to an analog of the common kinase inhibitor PP1 (Csk(AS)). Inhibition of Csk(AS) in thymocytes, without engagement of the TCR, induced potent activation of SFKs and proximal TCR signaling up to phospholipase C-γ1 (PLC-γ1). Unexp ...[more]