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Altered cingulate and insular cortex activation during risk-taking in methamphetamine dependence: losses lose impact.


ABSTRACT: To determine if methamphetamine-dependent (MD) individuals exhibit behavioral or neural processing differences in risk-taking relative to healthy comparison participants (CTL).This was a cross-sectional study comparing two groups' behavior on a risk-taking task and neural processing as assessed using functional magnetic resonance imaging (fMRI).The study was conducted in an in-patient treatment center and a research fMRI facility in the United States.Sixty-eight recently abstinent MD individuals recruited from a treatment program and 40 CTL recruited from the community completed the study.The study assessed risk-taking behavior (overall and post-loss) using the Risky Gains Task (RGT), sensation-seeking, impulsivity and blood-oxygenation-level-dependent activation in the brain during the decision phase of the RGT.Relative to CTL, MD displayed decreased activation in the bilateral rostral anterior cingulate cortex (ACC) and greater activation in the left insula across risky and safe decisions (P?

SUBMITTER: Gowin JL 

PROVIDER: S-EPMC3947108 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Altered cingulate and insular cortex activation during risk-taking in methamphetamine dependence: losses lose impact.

Gowin Joshua L JL   Stewart Jennifer L JL   May April C AC   Ball Tali M TM   Wittmann Marc M   Tapert Susan F SF   Paulus Martin P MP  

Addiction (Abingdon, England) 20131024 2


<h4>Aims</h4>To determine if methamphetamine-dependent (MD) individuals exhibit behavioral or neural processing differences in risk-taking relative to healthy comparison participants (CTL).<h4>Design</h4>This was a cross-sectional study comparing two groups' behavior on a risk-taking task and neural processing as assessed using functional magnetic resonance imaging (fMRI).<h4>Settings</h4>The study was conducted in an in-patient treatment center and a research fMRI facility in the United States.  ...[more]

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