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Cell migration driven by cooperative substrate deformation patterns.

ABSTRACT: Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.

SUBMITTER: Angelini TE

PROVIDER: S-EPMC3947506 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Cell migration driven by cooperative substrate deformation patterns.

Angelini Thomas E TE Hannezo Edouard E Trepat Xavier X Fredberg Jeffrey J JJ Weitz David A DA

Physical review letters 20100423 16

Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation ...[more]

PMID: 20482085

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