Ontology highlight
ABSTRACT:
SUBMITTER: Sanidas I
PROVIDER: S-EPMC3947584 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Sanidas Ioannis I Polytarchou Christos C Hatziapostolou Maria M Ezell Scott A SA Kottakis Filippos F Hu Lan L Guo Ailan A Xie Jianxin J Comb Michael J MJ Iliopoulos Dimitrios D Tsichlis Philip N PN
Molecular cell 20140123 4
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity. One of the top cellular functions differentially regulated by Akt isoforms is RNA processing. IWS1, an RNA processing regulator, is phosphorylated by Akt3 and Akt1 at Ser720/Thr721. The latter is required for the recruitment of SETD2 to the RNA Pol II complex. SETD2 trimethylates histone H3 at K36 during ...[more]