H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity.
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ABSTRACT:
SUBMITTER: Manley E
PROVIDER: S-EPMC3947657 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
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H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity.
Manley Eugene E Waxman David J DJ
Cancer letters 20131212 1
Cancer stem-like cells were isolated from several human tumor cell lines by limiting dilution assays and holoclone morphology, followed by assessment of self-renewal capacity, tumor growth, vascularity, and blood perfusion. H460 holoclone-derived tumors grew slower than parental H460 tumors, but displayed significantly increased microvessel density and tumor blood perfusion. Microarray analysis identified 177 differentially regulated genes in the holoclone-derived tumors, of which 47 were associ ...[more]
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