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Site-selective, cleavable linkers: quality control and the characterization of small molecules on microelectrode arrays.


ABSTRACT: A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.

SUBMITTER: Bi B 

PROVIDER: S-EPMC3947835 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Site-selective, cleavable linkers: quality control and the characterization of small molecules on microelectrode arrays.

Bi Bo B   Huang Richard Y-C RY   Maurer Karl K   Chen Ceng C   Moeller Kevin D KD  

The Journal of organic chemistry 20111010 21


A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to  ...[more]

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