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Site-selective, cleavable linkers: quality control and the characterization of small molecules on microelectrode arrays.

ABSTRACT: A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.

SUBMITTER: Bi B

PROVIDER: S-EPMC3947835 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Site-selective, cleavable linkers: quality control and the characterization of small molecules on microelectrode arrays.

Bi Bo B Huang Richard Y-C RY Maurer Karl K Chen Ceng C Moeller Kevin D KD

The Journal of organic chemistry 20111010 21

A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to ...[more]

PMID: 21958106

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