Ontology highlight
ABSTRACT:
SUBMITTER: Gagne JJ
PROVIDER: S-EPMC3947906 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Gagne J J JJ Glynn R J RJ Rassen J A JA Walker A M AM Daniel G W GW Sridhar G G Schneeweiss S S
Clinical pharmacology and therapeutics 20120516 1
We developed a semi-automated active monitoring system that uses sequential matched-cohort analyses to assess drug safety across a distributed network of longitudinal electronic health-care data. In a retrospective analysis, we show that the system would have identified cerivastatin-induced rhabdomyolysis. In this study, we evaluated whether the system would generate alerts for three drug-outcome pairs: rosuvastatin and rhabdomyolysis (known null association), rosuvastatin and diabetes mellitus, ...[more]