Ontology highlight
ABSTRACT:
SUBMITTER: Ouk T
PROVIDER: S-EPMC3948136 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Ouk Thavarak T Gautier Sophie S Pétrault Maud M Montaigne David D Maréchal Xavier X Masse Isabelle I Devedjian Jean-Christophe JC Deplanque Dominique D Bastide Michèle M Nevière Rémi R Duriez Patrick P Staels Bart B Pasquier Florence F Leys Didier D Bordet Régis R
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140108 3
In stroke, there is an imperative need to develop disease-modifying drugs able to (1) induce neuroprotection and vasculoprotection, (2) modulate recovery and brain plasticity, and (3) limit the short-term motor and cognitive consequences. We hypothesized that fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, could exert a beneficial effect on immediate and short-term poststroke consequences related to its pleiotropic mechanisms. Rats or mice were subjected to focal is ...[more]