Ontology highlight
ABSTRACT:
SUBMITTER: Root ED
PROVIDER: S-EPMC3948245 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Root Elisabeth Dowling ED Lucero Marilla M Nohynek Hanna H Anthamatten Peter P Thomas Deborah S K DS Tallo Veronica V Tanskanen Antti A Quiambao Beatriz P BP Puumalainen Taneli T Lupisan Socorro P SP Ruutu Petri P Ladesma Erma E Williams Gail M GM Riley Ian I Simões Eric A F EA
Proceedings of the National Academy of Sciences of the United States of America 20140218 9
Pneumococcal conjugate vaccines (PCVs) have demonstrated efficacy against childhood pneumococcal disease in several regions globally. We demonstrate how spatial epidemiological analysis of a PCV trial can assist in developing vaccination strategies that target specific geographic subpopulations at greater risk for pneumococcal pneumonia. We conducted a secondary analysis of a randomized, placebo-controlled, double-blind vaccine trial that examined the efficacy of an 11-valent PCV among children ...[more]