Ontology highlight
ABSTRACT:
SUBMITTER: Xue Y
PROVIDER: S-EPMC3948596 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Xue Yun Y Zhao Zhan-Qin ZQ Hong Dun D Zhang Hong-Jun HJ Chen Hai-Xiao HX Fan Shun-Wu SW
Genetic testing and molecular biomarkers 20140104 3
P-glycoprotein (P-gp) is present in various tissue cells, required for the pumping of lipophilic drugs (including glucocorticoids) out of cells. We hypothesized that polymorphisms in the P-gp encoding gene (multidrug-resistant transporter-1 [MDR1]) are related to individual differences in glucocorticoid sensitivity and the development of glucocorticoid-induced avascular necrosis of the femoral head (GANFH). In this case-control study, we genotyped three known single-nucleotide polymorphisms (SNP ...[more]