Dataset Information

Latent TB infection diagnosis in population exposed to TB subjects in close and poor ventilated high TB endemic zone in India.

ABSTRACT:

Background

The present study was designed to investigate the utility of Quantiferon TB gold (QFT-G) and Tuberculin skin test (TST) for diagnosis of latent TB infection (LTBI) in high crowding TB endemic zone of Nagpur, India and their comparison with associated risk factors.

Methods

Out of 342 eligible participants, QFT-G and TST were performed in 162 participants.

Results

The prevalence of LTBI observed according to QFT-G and TST was 48% and 42% respectively, with an agreement of 52.47%. QFT-G positivity was associated with age while TST positivity was associated with body mass index (BMI). Duration of exposure emerged as a key risk factor significantly associated with both the tests.

Conclusion

The prevalence of LTBI was quite high in the studied zone as detected by both the evaluated tests and thus, the combination of both the tests will be best predictive for LTBI in such high TB endemic regions.

SUBMITTER: Kashyap RS

PROVIDER: S-EPMC3948673 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Latent TB infection diagnosis in population exposed to TB subjects in close and poor ventilated high TB endemic zone in India.

Kashyap Rajpal S RS Nayak Amit R AR Gaherwar Hari M HM Husain Aliabbas A AA Shekhawat Seema D SD Jain Ruchika K RK Panchbhai Milind S MS Raje Dhananjay V DV Purohit Hemant J HJ Taori Girdhar M GM Daginawala Hatim F HF

PloS one 20140310 3

<h4>Background</h4>The present study was designed to investigate the utility of Quantiferon TB gold (QFT-G) and Tuberculin skin test (TST) for diagnosis of latent TB infection (LTBI) in high crowding TB endemic zone of Nagpur, India and their comparison with associated risk factors.<h4>Methods</h4>Out of 342 eligible participants, QFT-G and TST were performed in 162 participants.<h4>Results</h4>The prevalence of LTBI observed according to QFT-G and TST was 48% and 42% respectively, with an agree ...[more]

PMID: 24614179

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Project description:BackgroundTuberculosis (TB) in prisons usually occurs at higher rates than in the general population, especially in developing countries. TB has been reported as the most common cause of death among prisoners. Studies have shown limitations for early detection of TB in prisons that seem to result from mistaken concepts about TB, delayed diagnosis mainly due to the naturalization of lack of healthcare for this population METHODS: A scoping review was performed using the methodology of the Joanna Briggs Institute to assess "What are the scientific evidences on the epidemiology of TB in the prison system?". Then, a meta-analysis was performed to assess the prevalence of TB (active and latent) TB in prisoners. The results are presented as prevalence, in percentage, through random effects models, with a confidence interval of 95%.ResultsRegarding active TB, the results of the metanalysis showed that countries with a high burden of TB had a prevalence of 3.54% [2.71; 4.63], countries not considered to be high burden TB countries had a prevalence of 1.43% [0.86; 2.37]. Latent TB had a prevalence of 51.61% [39.46; 63.58] in high TB burden countries and a prevalence of 40.24% [23.51; 59.61] in countries with low TB burden. In terms of development, in low- and lower-middle-income countries, the prevalence of active TB was 3.13% [1.84; 5.29] and in high- and upper-middle income countries the prevalence was 2.25% [1.70; 2.99]. The prevalence of latent TB in high- and middle-income countries was 43.77% [28.61; 60.18] and of 49.42% [45.91; 52.94] in low and lower middle-income countries.ConclusionOur analysis suggests that TB, and probably other infectious diseases, find fertile ground in prisons where previous acquire social disadvantages seem to thrive-therefore, TB in prisons is a global public health problem and effective strategies are needed to control the disease are needed targeting the prison environment, including rapid health assessments to understand each context and to implement tailored and precision interventions.

Dataset Information

Latent TB infection diagnosis in population exposed to TB subjects in close and poor ventilated high TB endemic zone in India.

Background

Methods

Results

Conclusion

Publications

Latent TB infection diagnosis in population exposed to TB subjects in close and poor ventilated high TB endemic zone in India.

Similar Datasets

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