Ontology highlight
ABSTRACT:
SUBMITTER: Thein S
PROVIDER: S-EPMC3948843 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Thein Soe S Tao-Cheng Jung-Hwa JH Li Yan Y Bayer K Ulrich KU Reese Thomas S TS Dosemeci Ayse A
PloS one 20140310 3
NMDA treatment of cultured hippocampal neurons causes recruitment of CYLD, as well as CaMKII, to the postsynaptic density (PSD), as shown by immunoelectron microscopy. Recruitment of CYLD, a deubiquitinase specific for K63-linked polyubiquitins, is blocked by pre-treatment with tatCN21, a CaMKII inhibitor, at a concentration that inhibits the translocation of CaMKII to the PSD. Furthermore, CaMKII co-immunoprecipitates with CYLD from solubilized PSD fractions, indicating an association between t ...[more]