Ontology highlight
ABSTRACT:
SUBMITTER: Geerts CJ
PROVIDER: S-EPMC3948876 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Geerts Cornelia J CJ Jacobsen Linda L van de Bospoort Rhea R Verhage Matthijs M Groffen Alexander J A AJ
PloS one 20140310 3
Protein modification by Small Ubiquitin-like MOdifier (SUMO) entities is involved in a number of neuronal functions, including synaptogenesis and synaptic plasticity. Tomosyn-1 (syntaxin-binding protein 5; STXPB5) binds to t-SNARE (Soluble NSF Attachment Protein Receptor) proteins to regulate neurotransmission and is one of the few neuronal SUMO substrate proteins identified. Here we used yeast two-hybrid screening to show that tomosyn-1 interacts with the SUMO E3 ligase PIASγ (Protein Inhibitor ...[more]