Ontology highlight
ABSTRACT:
SUBMITTER: Quinn MJ
PROVIDER: S-EPMC3949420 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Quinn Matthew J MJ Resch Craig T CT Sun Jonathan J Lind Erin J EJ Dibrov Pavel P Häse Claudia C CC
Microbiology (Reading, England) 20120112 Pt 4
Vibrio cholerae has adapted to a wide range of salinity, pH and osmotic conditions, enabling it to survive passage through the host and persist in the environment. Among the many proteins responsible for bacterial survival under these diverse conditions, we have identified Vc-NhaP1 as a K(+)(Na(+))/H(+) antiporter essential for V. cholerae growth at low environmental pH. Deletion of the V. cholerae nhaP1 gene caused growth inhibition when external potassium was either limited (100 mM and below) ...[more]