Ontology highlight
ABSTRACT:
SUBMITTER: Miska J
PROVIDER: S-EPMC3949570 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20140224 3
Real-time imaging studies are reshaping immunological paradigms, but a visual framework is lacking for self-antigen-specific T cells at the effector phase in target tissues. To address this issue, we conducted intravital, longitudinal imaging analyses of cellular behavior in nonlymphoid target tissues to illustrate some key aspects of T cell biology. We used mouse models of T cell-mediated damage and protection of pancreatic islet grafts. Both CD4(+) and CD8(+) effector T (Teff) lymphocytes dire ...[more]