Ontology highlight
ABSTRACT:
SUBMITTER: Sewell-Loftin MK
PROVIDER: S-EPMC3950274 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Sewell-Loftin Mary Kathryn MK DeLaughter Daniel M DM Peacock Jon R JR Brown Christopher B CB Baldwin H Scott HS Barnett Joey V JV Merryman W David WD
Biomaterials 20140114 9
Epithelial-to-mesenchymal transition (EMT) of endocardial cells is a critical initial step in the formation of heart valves. The collagen gel in vitro model has provided significant information on the role of growth factors regulating EMT but has not permitted investigation of mechanical factors. Therefore we sought to develop a system to probe the effects of mechanical inputs on endocardial EMT by incorporating hyaluronic acid (HA), the primary component of endocardial cushions in developing he ...[more]