Ontology highlight
ABSTRACT:
SUBMITTER: Brzoska K
PROVIDER: S-EPMC3950616 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Brzóska Kamil K Stępkowski Tomasz M TM Kruszewski Marcin M
Molecular and cellular biochemistry 20140105 1-2
Pirin, a product of the PIR gene, is an iron-binding protein acting as a transcriptional coregulator implicated in the regulation of the NF-κB-related transcription via interaction with RelA (p65), as well as BCL3 and NF-κB1 (p50) proteins. Alterations in pirin expression were observed in various tumors and under oxidative stress conditions. The aim of the present work was to analyze the regulation of the transcription of the human PIR gene. Using constructs containing a different sized PIR prom ...[more]