Ontology highlight
ABSTRACT:
SUBMITTER: Peng CH
PROVIDER: S-EPMC3950678 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Peng Chien-Hua CH Jiang Yi-Zhi YZ Tai An-Shun AS Liu Chun-Bin CB Peng Shih-Chi SC Liao Chun-Ta CT Yen Tzu-Chen TC Hsieh Wen-Ping WP
Nucleic acids research 20131209 5
Deciphering the causal networks of gene interactions is critical for identifying disease pathways and disease-causing genes. We introduce a method to reconstruct causal networks based on exploring phenotype-specific modules in the human interactome and including the expression quantitative trait loci (eQTLs) that underlie the joint expression variation of each module. Closely associated eQTLs help anchor the orientation of the network. To overcome the inherent computational complexity of causal ...[more]