Ontology highlight
ABSTRACT:
SUBMITTER: Witzig TE
PROVIDER: S-EPMC3951424 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Witzig Thomas E TE Wiseman Gregory A GA Maurer Matthew J MJ Habermann Thomas M TM Micallef Ivana N M IN Nowakowski Grzegorz S GS Ansell Stephen M SM Colgan Joseph P JP Inwards David J DJ Porrata Luis F LF Link Brian K BK Zent Clive S CS Johnston Patrick B PB Shanafelt Tait D TD Allmer Cristine C Asmann Yan W YW Gupta Mamta M Ballas Zuhair K ZK Smith Brian J BJ Weiner George J GJ
American journal of hematology 20130612 7
Radioimmunotherapy (RIT) for relapsed indolent non-Hodgkin lymphoma produces overall response rates (ORR) of 80% with mostly partial remissions. Synthetic CpG oligonucleotides change the phenotype of malignant B-cells, are immunostimulatory, and can produce responses when injected intratumorally and combined with conventional radiation. In this phase I trial, we tested systemic administration of both CpG and RIT. Eligible patients had biopsy-proven previously treated CD20+ B-cell NHL and met cri ...[more]