Unknown

Dataset Information

0

Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies.


ABSTRACT: Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization. Cohesins mediate sister chromatid cohesion and cellular long-distance chromatin interactions affecting genome maintenance and gene expression. Discoveries of mutations in cohesin's subunits and its regulator proteins in human developmental disorders, so-called "cohesinopathies," reveal crucial roles for cohesins in development and cellular growth and differentiation. In this review, we discuss the latest findings concerning cohesin's functions in higher-order chromatin architecture organization and gene regulation and new insight gained from studies of cohesinopathies. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.

SUBMITTER: Ball AR 

PROVIDER: S-EPMC3951616 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies.

Ball Alexander R AR   Chen Yen-Yun YY   Yokomori Kyoko K  

Biochimica et biophysica acta 20131122 3


Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization. Cohesins mediate sister chromatid cohesion and cellular long-distance chromatin interactions affecting genome maintenance and gene expression. Discoveries of mutations in cohesin's subunits and its regulator proteins in human developmental disorders, so-called "cohesinopathies," reveal crucial roles  ...[more]

Similar Datasets

| S-EPMC8357140 | biostudies-literature
| S-EPMC2672303 | biostudies-literature
| S-EPMC4455826 | biostudies-literature
| S-EPMC5070902 | biostudies-other
| S-EPMC5551346 | biostudies-other
| S-EPMC8976879 | biostudies-literature
| S-EPMC3976103 | biostudies-literature
| S-EPMC5446754 | biostudies-literature
| S-EPMC4581358 | biostudies-other
| S-SCDT-EMBOR-2022-54853V1 | biostudies-other