Ontology highlight
ABSTRACT:
SUBMITTER: Ball AR
PROVIDER: S-EPMC3951616 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Ball Alexander R AR Chen Yen-Yun YY Yokomori Kyoko K
Biochimica et biophysica acta 20131122 3
Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization. Cohesins mediate sister chromatid cohesion and cellular long-distance chromatin interactions affecting genome maintenance and gene expression. Discoveries of mutations in cohesin's subunits and its regulator proteins in human developmental disorders, so-called "cohesinopathies," reveal crucial roles ...[more]