Ontology highlight
ABSTRACT:
SUBMITTER: Ronderos DS
PROVIDER: S-EPMC3951695 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Ronderos David S DS Lin Chun-Chieh CC Potter Christopher J CJ Smith Dean P DP
The Journal of neuroscience : the official journal of the Society for Neuroscience 20140301 11
We set out to deorphanize a subset of putative Drosophila odorant receptors expressed in trichoid sensilla using a transgenic in vivo misexpression approach. We identified farnesol as a potent and specific activator for the orphan odorant receptor Or83c. Farnesol is an intermediate in juvenile hormone biosynthesis, but is also produced by ripe citrus fruit peels. Here, we show that farnesol stimulates robust activation of Or83c-expressing olfactory neurons, even at high dilutions. The CD36 homol ...[more]