Ontology highlight
ABSTRACT:
SUBMITTER: Bonham KS
PROVIDER: S-EPMC3951743 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Bonham Kevin S KS Orzalli Megan H MH Hayashi Kachiko K Wolf Amaya I AI Glanemann Christoph C Weninger Wolfgang W Iwasaki Akiko A Knipe David M DM Kagan Jonathan C JC
Cell 20140201 4
The Toll-like receptors (TLRs) of the innate immune system are unusual in that individual family members are located on different organelles, yet most activate a common signaling pathway important for host defense. It remains unclear how this common signaling pathway can be activated from multiple subcellular locations. Here, we report that, in response to natural activators of innate immunity, the sorting adaptor TIRAP regulates TLR signaling from the plasma membrane and endosomes. TLR signalin ...[more]