Ontology highlight
ABSTRACT:
SUBMITTER: Basak S
PROVIDER: S-EPMC3951836 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Molecular cell 20080501 3
The p53 tumor suppressor restricts tumorigenesis through the transcriptional activation of target genes involved in cell-cycle arrest and apoptosis. Here, we identify Prl-3 (phosphatase of regenerating liver-3) as a p53-inducible gene. Whereas previous studies implicated Prl-3 in metastasis because of its overexpression in metastatic human colorectal cancer and its ability to promote invasiveness and motility, we demonstrate here that Prl-3 is an important cell-cycle regulator. Consistent with a ...[more]