Ontology highlight
ABSTRACT:
SUBMITTER: Dominguez E
PROVIDER: S-EPMC3953460 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Dominguez Eduardo E Galmozzi Andrea A Chang Jae Won JW Hsu Ku-Lung KL Pawlak Joanna J Li Weiwei W Godio Cristina C Thomas Jason J Partida David D Niessen Sherry S O'Brien Paul E PE Russell Aaron P AP Watt Matthew J MJ Nomura Daniel K DK Cravatt Benjamin F BF Saez Enrique E
Nature chemical biology 20131222 2
Phenotypic screening is making a comeback in drug discovery as the maturation of chemical proteomics methods has facilitated target identification for bioactive small molecules. A limitation of these approaches is that time-consuming genetic methods or other means are often required to determine the biologically relevant target (or targets) from among multiple protein-compound interactions that are typically detected. Here, we have combined phenotypic screening of a directed small-molecule libra ...[more]