Lipin-1 and lipin-3 together determine adiposity in vivo.
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ABSTRACT:
SUBMITTER: Csaki LS
PROVIDER: S-EPMC3953701 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Lipin-1 and lipin-3 together determine adiposity in vivo.
Csaki Lauren S LS Dwyer Jennifer R JR Li Xia X Nguyen Michael H K MH Dewald Jay J Brindley David N DN Lusis Aldons J AJ Yoshinaga Yuko Y de Jong Pieter P Fong Loren L Young Stephen G SG Reue Karen K
Molecular metabolism 20131128 2
The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we identified a cooperative relationship between lipin-3 and lipin-1 that influences adipogenesis in vitro and adiposity in vivo. Furthermore, natural genetic variations in Lpin1 and Lpin3 expression levels across 100 ...[more]
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