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Lipin-1 and lipin-3 together determine adiposity in vivo.

ABSTRACT: The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we identified a cooperative relationship between lipin-3 and lipin-1 that influences adipogenesis in vitro and adiposity in vivo. Furthermore, natural genetic variations in Lpin1 and Lpin3 expression levels across 100 mouse strains correlate with adiposity. Analysis of PAP activity in additional metabolic tissues from lipin single- and double-knockout mice also revealed roles for lipin-1 and lipin-3 in spleen, kidney, and liver, for lipin-1 alone in heart and skeletal muscle, and for lipin-1 and lipin-2 in lung and brain. Our findings establish that lipin-1 and lipin-3 cooperate in vivo to determine adipose tissue PAP activity and adiposity, and may have implications in understanding the protection of lipin-1-deficient humans from overt lipodystrophy.

SUBMITTER: Csaki LS

PROVIDER: S-EPMC3953701 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Lipin-1 and lipin-3 together determine adiposity in vivo.

Csaki Lauren S LS Dwyer Jennifer R JR Li Xia X Nguyen Michael H K MH Dewald Jay J Brindley David N DN Lusis Aldons J AJ Yoshinaga Yuko Y de Jong Pieter P Fong Loren L Young Stephen G SG Reue Karen K

Molecular metabolism 20131128 2

The lipin protein family of phosphatidate phosphatases has an established role in triacylglycerol synthesis and storage. Physiological roles for lipin-1 and lipin-2 have been identified, but the role of lipin-3 has remained mysterious. Using lipin single- and double-knockout models we identified a cooperative relationship between lipin-3 and lipin-1 that influences adipogenesis in vitro and adiposity in vivo. Furthermore, natural genetic variations in Lpin1 and Lpin3 expression levels across 100 ...[more]

PMID: 24634820

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Lipin-1 and lipin-3 together determine adiposity in vivo.

Publications

Lipin-1 and lipin-3 together determine adiposity in vivo.

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