Ontology highlight
ABSTRACT:
SUBMITTER: Kathawala RJ
PROVIDER: S-EPMC3954439 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Kathawala Rishil J RJ Sodani Kamlesh K Chen Kang K Patel Atish A Abuznait Alaa H AH Anreddy Nagaraju N Sun Yue-Li YL Kaddoumi Amal A Ashby Charles R CR Chen Zhe-Sheng ZS
Molecular cancer therapeutics 20140115 3
Paclitaxel displays clinical activity against a wide variety of solid tumors. However, resistance to paclitaxel significantly attenuates the response to chemotherapy. The ABC transporter subfamily C member 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7) efflux transporter, is a major mediator of paclitaxel resistance. In this study, we show that masitinib, a small molecule stem-cell growth factor receptor (c-Kit) tyrosine kinase inhibitor, at nontoxic concentrations, significant ...[more]