Ontology highlight
ABSTRACT:
SUBMITTER: Sanada C
PROVIDER: S-EPMC3954540 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Sanada Chad C Kuo Chung-Jung CJ Colletti Evan J EJ Soland Melisa M Mokhtari Saloomeh S Knovich Mary Ann MA Owen John J Zanjani Esmail D ED Porada Christopher D CD Almeida-Porada Graça G
Journal of cellular physiology 20130501 5
Besides the liver, it has been difficult to identify which organ(s) and/or cellular component(s) contribute significantly to the production of human FVIII:c (FVIII). Thus far, only endothelial cells have been shown to constitute a robust extrahepatic source of FVIII, possibly explaining both the diverse presence of FVIII mRNA in the body, and the observed increase in FVIII levels during liver failure. Here, we investigate whether human mesenchymal stem cells (MSC), ubiquitously present in differ ...[more]