Ontology highlight
ABSTRACT:
SUBMITTER: Chiang MJ
PROVIDER: S-EPMC3954559 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140224 9
Proteins as well as small molecules have demonstrated success as therapeutic agents, but their pharmacologic properties sometimes fall short against particular drug targets. Although the adenosine 2a receptor (A(2A)R) has been identified as a promising target for immunotherapy, small molecule A(2A)R agonists have suffered from short pharmacokinetic half-lives and the potential for toxicity by modulating nonimmune pathways. To overcome these limitations, we have tethered the A(2A)R agonist CGS-21 ...[more]