3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture.
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ABSTRACT:
SUBMITTER: Kolewe ME
PROVIDER: S-EPMC3954574 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
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3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture.
Kolewe Martin E ME Park Hyoungshin H Gray Caprice C Ye Xiaofeng X Langer Robert R Freed Lisa E LE
Advanced materials (Deerfield Beach, Fla.) 20130614 32
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. ...[more]
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