Ontology highlight
ABSTRACT:
SUBMITTER: Lyumkis D
PROVIDER: S-EPMC3954647 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20131031 6165
The HIV-1 envelope glycoprotein (Env) trimer contains the receptor binding sites and membrane fusion machinery that introduce the viral genome into the host cell. As the only target for broadly neutralizing antibodies (bnAbs), Env is a focus for rational vaccine design. We present a cryo-electron microscopy reconstruction and structural model of a cleaved, soluble Env trimer (termed BG505 SOSIP.664 gp140) in complex with a CD4 binding site (CD4bs) bnAb, PGV04, at 5.8 angstrom resolution. The str ...[more]