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Absence of detectable HIV-1 viremia after treatment cessation in an infant.


ABSTRACT: An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.

SUBMITTER: Persaud D 

PROVIDER: S-EPMC3954754 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Absence of detectable HIV-1 viremia after treatment cessation in an infant.

Persaud Deborah D   Gay Hannah H   Ziemniak Carrie C   Chen Ya Hui YH   Piatak Michael M   Chun Tae-Wook TW   Strain Matthew M   Richman Douglas D   Luzuriaga Katherine K  

The New England journal of medicine 20131023 19


An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of  ...[more]

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