Neonatal immune-tolerance in mice does not prevent xenograft rejection.
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ABSTRACT:
SUBMITTER: Mattis VB
PROVIDER: S-EPMC3954854 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
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Neonatal immune-tolerance in mice does not prevent xenograft rejection.
Mattis Virginia B VB Wakeman Dustin R DR Tom Colton C Dodiya Hemraj B HB Yeung Sylvia Y SY Tran Andrew H AH Bernau Ksenija K Ornelas Loren L Sahabian Anais A Reidling Jack J Sareen Dhruv D Thompson Leslie M LM Kordower Jeffrey H JH Svendsen Clive N CN
Experimental neurology 20140116
Assessing the efficacy of human stem cell transplantation in rodent models is complicated by the significant immune rejection that occurs. Two recent reports have shown conflicting results using neonatal tolerance to xenografts in rats. Here we extend this approach to mice and assess whether neonatal tolerance can prevent the rapid rejection of xenografts. In three strains of neonatal immune-intact mice, using two different brain transplant regimes and three independent stem cell types, we concl ...[more]
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