RNA expression of the molecular signature genes for metastasis in colorectal cancer.

ABSTRACT: Colorectal cancer is an endemic disease in the western world. Search for molecular signatures present in primary tumors that predict tumor metastasis potential has been proposed and in particular, a 17-gene molecular signature is associated with poor survival in breast cancer, prostate cancer, meduloblastoma and lymphoma in a recent study. Using quantitative real-time PCR assay (qPCR), our study observed tumor-normal differential RNA expression in 15 of these 17 genes in a cohort of 52 stage III colorectal cancer patients (all p<0.05), which signified the importance of these 17 signature genes in colorectal cancer. Although no significant correlation was found between tumor RNA levels of these 17 genes and some of clinical features (age, gender, and location, all p>0.05), two distinct grou

SUBMITTER: Carvalho L 

PROVIDER: S-EPMC3954856 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature