Ontology highlight
ABSTRACT:
SUBMITTER: Luz RA
PROVIDER: S-EPMC3955596 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Luz Ricardo Alves RA Xavier-Elsas Pedro P de Luca Bianca B Masid-de-Brito Daniela D Cauduro Priscila Soares PS Arcanjo Luiz Carlos Gondar LC dos Santos Ana Carolina Cordeiro Faria AC de Oliveira Ivi Cristina Maria IC Gaspar-Elsas Maria Ignez Capella MI
Mediators of inflammation 20140225
The roles of eosinophils in antimicrobial defense remain incompletely understood. In ovalbumin-sensitized mice, eosinophils are selectively recruited to the peritoneal cavity by antigen, eotaxin, or leukotriene(LT)B4, a 5-lipoxygenase (5-LO) metabolite. 5-LO blockade prevents responses to both antigen and eotaxin. We examined responses to eotaxin in the absence of sensitization and their dependence on 5-LO. BALB/c or PAS mice and their mutants (5-LO-deficient ALOX; eosinophil-deficient GATA-1) w ...[more]